Tecoland supplies high purity Doxorubicin HCl bulk Active Pharmaceutical Ingredient (API) produced by GMP facility. We custom package for orders ranging from milligram to bulk quantity. Welcome to contact us with your specific request.

The following information is provided for general information purposes ONLY.

Description of Doxorubicin HCl

Doxorubicin is used alone and in combination with other drugs for treatment of tumors including malignant lymphomas and leukemias. A new liposomal version of this drug called Doxil has been recently approvedl as a Kaposiis sarcoma treatment. Liposomal means that the drug is put inside tiny bules of fat. These fat bules should take more of the drug to where itís needed, and reduce side effects.

Managing side effects of Doxorubicin HCl

Notify your doctor promptly if you have fever, sore throat, signs of infection, bleeding gums, bruising, blood in stools or urine, and increased fatigue. Avoid crowds and persons with known infections. Use a soft toothbrush and electric razor and avoid falls. Do not drink alcoholic beverages or take drugs containing aspirin because these can cause gastric bleeding. Rinse your mouth with warm salt water after eating and drinking. Practice contraception during treatment and for at least 4 months after therapy is concluded. Notify your doctor immediately if you have irregular heart beat, shortness of breath, or swelling of legs. Tell your doctor if you get a skin irritation at the site of previous radiation therapy. Do not receive any vaccinations without discussing with your doctor.

Possible side effects of Doxorubicin HCl

• Hair loss usually starts 3–4 weeks after the first dose of doxorubicin, although it may happen earlier. Hair may be lost completely. You may also have thinning and loss of eyelashes, eyebrows and other body hair. This is temporary and the hair will regrow once the treatment ends. To help reduce hair loss, scalp cooling may be suitable for some people.

• Nausea (feeling sick) and vomiting There are now very effective anti-sickness drugs to prevent or greatly reduce nausea and vomiting.  If it occurs it may begin a few hours after the treatment is given and last for up to a day. If the sickness is not controlled, or continues, tell your doctor, who can prescribe other anti-sickness drugs that may be more effective.

• Lowered resistance to infection Doxorubicin can reduce the production of white blood cells by the bone marrow, making you more prone to infection. This effect can begin seven days after treatment has been given and usually reaches its lowest point 10–14 days after chemotherapy. Your blood cells will then increase steadily and will usually have returned to normal before your next course of chemotherapy is due. Contact your doctor or the hospital straightaway if: Your temperature goes above 38°C (100.5°F). You suddenly feel unwell (even with a normal temperature). You will have a blood test before having more chemotherapy, to make sure that your cells have recovered. Occasionally it may be necessary to delay your treatment if your blood count is still low.

• Bruising or bleeding  Doxorubicin can reduce the production of platelets (which help the blood to clot). Let your doctor know if you have any unexplained bruising or bleeding.

• Anaemia (low number of red blood cells) While having treatment with doxorubicin you may become anaemic. This may make you feel tired and breathless.

• Sore mouth and taste change Your mouth may become sore, or you may notice small ulcers during this treatment. Drinking plenty of fluids and cleaning your teeth regularly and gently with a soft toothbrush can help to reduce the risk of this happening. Tell your doctor if you do have any of these problems, as special mouthwashes and medicines to prevent or clear any mouth infection can be prescribed. You may notice that your food tastes different. Normal taste will come back after the treatment finishes.

• Discoloured urine Your urine may become a pink-red color. This may last up to 24 hours after you have had the doxorubicin, and is due to the color of the drug. It is quite normal.

• Skin changes Your skin may darken, due to excess production of pigment. This usually returns to normal a few months after the treatment has finished.

• Sensitivity to the sun While you are having doxorubicin, and for several months afterwards, you will be more sensitive to the sun, and your skin may burn more easily. You can still go out in the sun, but always wear a high protection factor sun cream and protective clothing.

• Tiredness and a general feeling of weakness It is important to allow yourself plenty of time to rest.

Disclaimer:

Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.