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Introduction of
Nitrendipine
When
Nitrendipine is given orally has high hepatic metabolism.
Hence a higher dose by oral route should be used than by I.V
route. It is highly protein bound.
Precautions while using Nitrendipine
Allergies :
Allergic reaction to nitrendipine may occur. Pregnancy:
Calcium channel blockers have not been studied in pregnant
women. However, studies in animals have shown that large doses
of calcium channel blockers cause birth defects, prolonged
pregnancy, poor bone development, and stillbirth.
Breast-feeding : Nitrendipine passes into breast milk, but
they have not been reported to cause problems in nursing
babies.Older adults:- Elderly people may be especially
sensitive to the effects of calcium channel blockers. This may
increase the chance of side effects during treatment.
Nitrendipine's Interactions With
Other Drugs
Interaction
with the following drugs have been reported: Acetazolamide,
Amphotericin B, Corticosteroids, Dichlorphenamide, Diuretics,
Methazolamide, Beta-blockers like acebutolol, atenolol,
betaxolol, carteolol, labetalol, metoprolol, nadolol,
oxprenolol, penbutolol, pindolol, propranolol, sotalol,
timolol : Effects of both may be increased. In addition,
adverse effects may occur if a calcium channel blocker or a
beta-blocker is stopped suddenly after use together.
Carbamazepine, Cyclosporine, Procainamide,Quinidine: Effects
of these drugss may be increased if they are used together
with calcium channel blockers. Digitalis glycosides : Effects
of these drugs may be potentiated if they are used with
calcium channel blockers. Disopyramide: Effects of calcium
channel blockers on the heart may be potentiated.
Disclaimer:
Information on this page is provided for general
information purposes. You should not make a clinical treatment
decision based on information contained in this page without
consulting other references including the package insert of
the drug, textbooks and where relevant, expert opinion. We
cannot be held responsible for any errors you make in
administering drugs mentioned on this page, nor for use of any
erroneous information contained on this page.
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