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Introduction of
Ranolazine
Ranolazine is used
with other medications to treat angina (chest pain or pressure
that is felt when the heart does not get enough oxygen) that
is a symptom of an ongoing condition. Ranolazine is used to
treat people who still experience angina even when they take
other medications to treat the condition. Ranolazine may
prevent episodes of angina, but it cannot be used to relieve
an episode of angina that has already begun. Ranolazine is in
a class of medications called anti-ischemics. The exact way
that ranolazine works is not known at this time.
How should Ranolazine be used
Ranolazine comes as
an extended-release (long-acting) tablet to take by mouth. It
is usually taken with or without food two times a day. Take
ranolazine at around the same times every day. Follow the
directions on your prescription label carefully, and ask your
doctor or pharmacist to explain any part you do not
understand. Take ranolazine exactly as directed. Do not take
more or less of it or take it more often than prescribed by
your doctor.
Swallow the tablets
whole; do not break, chew, or crush them.
Your doctor will
probably start you on a low dose of ranolazine and gradually
increase your dose.
Do not take
ranolazine to treat a sudden attack of angina. Your doctor
will tell you what you should do if you experience an attack
of angina. Make sure that you understand these directions.
Ranolazine may help
to control your condition but will not cure it. Continue to
take ranolazine even if you feel well. Do not stop taking
ranolazine without talking to your doctor.
Other uses for Ranolazine
Ranolazine may be
prescribed for other uses; ask your doctor or pharmacist for
more information.
Special precautions before taking Ranolazine
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tell your doctor
and pharmacist if you are allergic to ranolazine, any other
medications, or any of the ingredients in ranolazine
tablets. Ask your pharmacist for a list of the ingredients.
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tell your doctor
if you are taking any of the following medications: certain
antibiotics such as clarithromycin (Biaxin, in
Prevpac),erythromycin (E.E.S., E-Mycin, Erythrocin),
moxifloxacin (Avelox), sparfloxacin (Zagam) (not available
in the United States) and troleandomycin (TAO); certain
antifungals such as fluconazole (Diflucan), itraconazole (Sporanox),
ketoconazole (Nizoral), and voriconazole (Vfend);certain
antipsychotics (medications to treat mental illness)
including thioridazine (Mellaril) and ziprasidone (Geodon);
cisapride (Propulsid) (not available in the United
States);diltiazem (Cardizem, Tiazac, Dilacor); certain
medications to treat human immunodeficiency virus (HIV) or
acquired immunodeficiency syndrome (AIDS) such as atazanavir
(Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva),
indinavir (Crixivan), lopinavir (in Kaletra), nelfinavir (Viracept),
ritonavir (Norvir, in Kaletra), and saquinavir (Invirase);
medications for irregular heartbeat such as amiodarone (Cordarone,
Pacerone), disopyramide (Norpace), dofetilide (Tikosyn),
procainamide (Procanbid, Pronestyl), quinidine (Quinidex),
and sotalol (Betapace);pimozide (Orap); and verapamil (Calan,
Covera, Isoptin, Verelan). Your doctor may tell you not to
take ranolazine if you are taking one or more of these
medications.
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tell your doctor
and pharmacist what other prescription and nonprescription
medications, vitamins, nutritional supplements, and herbal
products you are taking or plan to take. Be sure to mention
any of the following: certain antidepressants such as
amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil),
desipramine (Norpramin), doxepin (Adapin, Sinequan),
imipramine (Tofranil), nortriptyline (Aventyl, Pamelor),
protriptyline (Vivactil), and trimipramine (Surmontil);cyclosporine
(Neoral, Sandimmune); digoxin (Lanoxicaps, Lanoxin); and
simvastatin (in Vytorin, Zocor). Your doctor may need to
change the doses of your medications or monitor you
carefully for side effects. Many other medications may also
interact with ranolazine, so be sure to tell your doctor
about all the medications you are taking, even those that do
not appear on this list or the list above.
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tell your doctor
if you have or have ever had a prolonged QT interval (a rare
heart problem that may cause fainting or irregular
heartbeat) or liver disease. Your doctor may tell you that
you should not take ranolazine.
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tell your doctor
if anyone in your family has or has ever had a prolonged QT
interval and if you or anyone in your family has or has ever
had a fast, slow, or irregular heartbeat; an abnormal
electrocardiogram (EKG, ECG, heart rhythm test), or low
levels of potassium in the blood. Also tell your doctor if
you have or have ever had kidneydisease.
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tell your doctor
if you are pregnant, plan to become pregnant, or are
breast-feeding. If you become pregnant while taking
ranolazine, call your doctor. You should not breast-feed
while taking ranolazine.
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you should know
that ranolazine may make you dizzy and lightheaded. Do not
drive a car, operate machinery, or participate in activities
requiring mental alertness and coordination until you know
how this medication affects you.
Side effects of Ranolazine
Ranolazine may cause
side effects. Tell your doctor if any of these symptoms are
severe or do not go away:
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nausea
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constipation
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headache
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dizziness
Some side effects
can be serious. If you experience either of these symptoms,
call your doctor immediately:
Ranolazine may cause
prolonged QT interval, a serious or life-threatening
condition. Talk to your doctor about the risks of taking this
medication.
Ranolazine may cause
other side effects. Call your doctor if you have any unusual
problems while taking this medication.
Disclaimer:
Information on this page is provided for general
information purposes. You should not make a clinical treatment
decision based on information contained in this page without
consulting other references including the package insert of
the drug, textbooks and where relevant, expert opinion. We
cannot be held responsible for any errors you make in
administering drugs mentioned on this page, nor for use of any
erroneous information contained on this page.
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