Tecoland supplies high purity Tegafur bulk Active Pharmaceutical Ingredient (API) produced by GMP facility. We custom package for orders ranging from milligram to bulk quantity. Welcome to contact us with your specific request.

The following information is provided for general information purposes ONLY.

Introduction of Tegafur

Tegafur-uracil is a combination of two chemotherapy drugs: tegafur and uracil. When the capsules are taken, the tegafur is taken up by the cancer cells and slowly develops into what is known as the active drug fluorouracil. Within the cells is an enzyme that breaks down the 5FU. However the uracil slows the breakdown of 5FU. This means that the 5FU stays in the cancer cells for longer and there is a higher concentration of 5FU in the tumour cells than when tegafur is given alone, or when the same dose of 5FU is given into a vein. 5FU itself has been used as a drug treatment for bowel cancer for almost 50 years.

Possible side effects of Tegafur

The known side effects of tegafur-uracil are not usually severe. The following are the most common:

Diarrhea can usually be easily controlled with medicines, but let your doctor know if it is severe or continues. If you have diarrhea it is important to drink plenty of fluids to replace the fluid lost.

Nausea and vomiting This is usually mild and there are now very effective anti-sickness drugs to prevent or reduce nausea and vomiting. If this does happen, it may begin a few hours after you have taken the drug. If the sickness is not controlled, or continues, tell your doctor, who can prescribe other anti-sickness drugs which may be more effective.

Fatigue It is important to allow yourself plenty of time to rest.

Lowered resistance to infection Tegafur-uracil can reduce the production of white blood cells by the bone marrow, making you more prone to infection. The extent to which your bone marrow is affected depends on the dose of chemotherapy you are given and whether you are being given other chemotherapy drugs at the same time. Your blood cells will usually have returned to normal before your next course of chemotherapy is due.

Contact your doctor or the hospital straightaway if:

• Your temperature goes above 38°C (100.5°F)

• You suddenly feel unwell (even with a normal temperature)

You will have a blood test before having more chemotherapy, to make sure that your cells have recovered. Occasionally it may be necessary to delay your treatment if your blood count is still low.

Bruising or bleeding  Tegafur can reduce the production of platelets (which help the blood to clot). Let your doctor know if you have any unexplained bruising or bleeding.

Anaemia  While having treatment with tegafur you may become anaemic. This may make you feel tired and breathless.

Disclaimer:

Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.